The Pilot and Feasibility Study (PFS) program of the UCLA: Digestive Diseases Research Core Center for the Study of Cell Signaling and Communication (UCLA:DDRCC-SigCo)  plays a key role in promoting multidisciplinary research to gain a deeper understanding of the basic biology of the digestive system and the mechanisms underlying the development of digestive disorders, which ultimately will have a significant impact on improving patient care. The PFS program will contribute to achieving this overarching goal by the following Specific Aims: 1) To provide funds for innovative research relevant to the UCLA: DDRCC-SigCo research programs leading to extramural funds; 2) To foster the career development of junior investigators by providing Core services and resources to acquire strong preliminary data and mentorship by established Center investigators; 3) To recruit established investigators new to the digestive system area of research who can bring new expertise and research skills and develop independent research programs relevant to the UCLA:DDRCC-Sig-Co research mission; 4) To provide the opportunity to established investigators with GI expertise to test innovative concepts that represent a substantial departure from their currently funded research; and 5) To facilitate and promote interactions and collaborations between UCLA:DDRCC-SigCo members and PFS awardees